Pharmacogenetics in type 2 diabetes: precision medicine or discovery tool?
نویسندگان
چکیده
منابع مشابه
A review on precision medicine and conducting pharmacogenetics tests of drugs
Precision medicine, the selection of treatment based on the genetic characteristics of patients, is one of the new paradigms of medical science. Using genetic characteristics and biomarkers, patients' response to different treatments is evaluated and finally, a specific one is selected for them. In other words, using genetic information or biomarkers, the safety, effectiveness and outcomes of t...
متن کاملThe Pharmacogenetics of Type 2 Diabetes: A Systematic Review
OBJECTIVE We performed a systematic review to identify which genetic variants predict response to diabetes medications. RESEARCH DESIGN AND METHODS We performed a search of electronic databases (PubMed, EMBASE, and Cochrane Database) and a manual search to identify original, longitudinal studies of the effect of diabetes medications on incident diabetes, HbA1c, fasting glucose, and postprandi...
متن کاملPharmacogenetics for type 2 diabetes: practical considerations for study design.
There is a relative dearth of studies designed to elucidate genetic variation that can explain differences in the response to diabetes pharmacotherapy. When designing such studies, appropriate consideration of the various nongenetic variables that can affect the treatment response is necessary. In addition, disease stage and prior pharmacotherapy also influence drug efficacy. Selecting the appr...
متن کاملPharmacogenetics and personalized treatment of type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a worldwide epidemic with considerable health and economic consequences. T2DM patients are often treated with more than one drug, including oral antidiabetic drugs (OAD) and drugs used to treat diabetic complications, such as dyslipidemia and hypertension. If genetic testing could be employed to predict treatment outcome, appropriate measures could be taken to...
متن کاملPersonalized medicine in Type 2 Diabetes
Type 2 diabetes (T2D) is a global public health concern, its prevalence in Asia, especially Taiwan, rising every year. The risk of developing T2D and diabetes complications is not only controlled by environmental but also by genetic factors. Genetic association studies have shown polymorphisms at specific loci may help identify individuals at greatest risk and response to oral antidiabetic drug...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2017
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-017-4227-1